INTRACRANIAL HEMORRHAGE DETECTION IN CT SCAN USING DEEP LEARNING

Authors

  • Anas Tharek Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia
  • Ahmad Sobri Muda Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
  • Aqilah Baseri Hudi Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.
  • Azzam Baseri Hudin Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia

DOI:

https://doi.org/10.32896/ajmedtech.v2n1.1-18

Keywords:

Artificaial intelligence, Deep learning, Convolutional neural network, Intracranial hemorrhage, CT Brain

Abstract

Missed detection of intracranial hemorrhage in Head CT scans has significantly impacted patient morbidity and mortality. Early detection of intracranial hemorrhage enables patients to receive appropriate treatment which resulted in a better outcome. Some doctors have limited experience in interpreting the CT scan hence increasing the probability to miss the hemorrhage. The main objective of this study is to develop an algorithm model capable of detecting intracranial hemorrhage in a head CT scan. We are using deep learning from a convolutional neural network (CNN) to produce this algorithm module. This was a cross-sectional study using secondary data, in which 200 data were collected from public datasets. All of the samples have been anonymized into secondary data. The algorithm model is trained using deep learning via a Jupyter Notebook platform. To analyze the algorithm model performance, a confusion matrix was used to measure the accuracy, sensitivity, specificity, precision, and F1 score. This study showed that from 200 training data, 95 samples were true positive, 95 samples were true negative, 7 samples were false positive, and 3 samples were false negative. This algorithm model shows high sensitivity (0.9694), high specificity (0.9314), high precision (0.9314), and high accuracy (0.9500) with an F1 score of 0.9500. This study has proven that deep learning by using CNN enables us to create an accurate classifier that can differentiate between head CT scan with intracranial hemorrhage and without hemorrhage.

 

The main objective of this study is to develop an algorithm model capable of detecting intracranial hemorrhage in a head CT scan. We are using deep learning from a convolutional neural network (CNN) to produce this algorithm module. This was a cross-sectional study using secondary data, in which 200 data were collected from public datasets. This dataset is owned by Abdul Kader Helwan, an academic staff at Al-Manar University of Tripoli, Lebanon. Permission to use the dataset for this research was officially obtained from the owner. All of samples have been anonymized into secondary data. The data is divided into train, validation, and test samples. The algorithm model is trained using deep learning via a Jupyter Notebook platform. To analyze the algorithm model performance, confusion matrix was used to measure the accuracy, sensitivity, specificity, precision, and F1 score.

 

This study showed that from 200 training data, 95 samples were true positive, 95 samples were true negative, 7 samples were false positive, and 3 samples were false negative. This algorithm model shows high sensitivity (0.9694), high specificity (0.9314), high precision (0.9314), and high accuracy (0.9500) with F1 score of 0.9500.

 

Hence, this study has proven that deep learning by using CNN enables us to create an accurate classifier that can differentiate between head CT scan with intracranial  hemorrhage and without hemorrhage.

References

K. Blennow et al., “Traumatic brain injuries,” Nature Reviews Disease Primers, vol. 2, pp. 1–19, 2016, doi: 10.1038/nrdp.2016.84.

J. Borsch, “Ovulationshemmer oder abtreibungspille? So wirken notfallkontrazeptiva,” Deutsche Apotheker Zeitung, vol. 153, no. 9, pp. 32–33, 2013.

A. M. Naidech, “Intracranial hemorrhage,” American Journal of Respiratory and Critical Care Medicine, vol. 184, no. 9, pp. 998–1006, 2011, doi: 10.1164/rccm.201103-0475CI.

G. Rath and B. Ray, “Head Injury: Assessment and Early Management,” Practice Guidelines in Anesthesia, no. January 2014, pp. 53–53, 2016, doi: 10.5005/jp/books/12644_7.

W. M. Strub, J. L. Leach, T. Tomsick, and A. Vagal, “Overnight preliminary head CT interpretations provided by residents: Locations of misidentified intracranial hemorrhage,” American Journal of Neuroradiology, vol. 28, no. 9, pp. 1679–1682, 2007, doi: 10.3174/ajnr.A0653.

J. S. Moon et al., “Prehospital neurologic deterioration in patients with intracerebral hemorrhage,” Critical Care Medicine, vol. 36, no. 1, pp. 172–175, 2008, doi: 10.1097/01.CCM.0000297876.62464.6B.

J. C. Hemphill et al., “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association,” Stroke, vol. 46, no. 7, pp. 2032–2060, 2015, doi: 10.1161/STR.0000000000000069.

B. E. Bejnordi et al., “Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer,” JAMA - Journal of the American Medical Association, vol. 318, no. 22, pp. 2199–2210, 2017, doi: 10.1001/jama.2017.14585.

A. Esteva et al., “Dermatologist-level classification of skin cancer with deep neural networks,” Nature, vol. 542, no. 7639, pp. 115–118, 2017, doi: 10.1038/nature21056.

V. Gulshan et al., “Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs,” JAMA - Journal of the American Medical Association, vol. 316, no. 22, pp. 2402–2410, 2016, doi: 10.1001/jama.2016.17216.

Y. Lecun, Y. Bengio, and G. Hinton, “Deep learning,” Nature, vol. 521, no. 7553, pp. 436–444, 2015, doi: 10.1038/nature14539.

C. Tang, Q. Zhu, W. Wu, W. Huang, C. Hong, and X. Niu, “PLANET: Improved Convolutional Neural Networks with Image Enhancement for Image Classification,” Mathematical Problems in Engineering, vol. 2020, 2020, doi: 10.1155/2020/1245924.

A. Usha Ruby, P. Theerthagiri, I. Jeena Jacob, and Y. Vamsidhar, “Binary cross entropy with deep learning technique for image classification,” International Journal of Advanced Trends in Computer Science and Engineering, vol. 9, no. 4, pp. 5393–5397, 2020, doi: 10.30534/ijatcse/2020/175942020.

A. Pinto, “Spectrum of diagnostic errors in radiology,” World Journal of Radiology, vol. 2, no. 10, p. 377, 2010, doi: 10.4329/wjr.v2.i10.377.

A. Helwan, G. El-Fakhri, H. Sasani, and D. Uzun Ozsahin, “Deep networks in identifying CT brain hemorrhage,” Journal of Intelligent and Fuzzy Systems, vol. 35, no. 2, pp. 2215–2228, 2018, doi: 10.3233/JIFS-172261.

P. Lakhani, D. L. Gray, C. R. Pett, P. Nagy, and G. Shih, “Hello World Deep Learning in Medical Imaging,” 2018.

R. Browse and J. Glasgow, “Programming Artificial Languages for,” vol. 11, pp. 431–448, 1984.

M. Matsugu, K. Mori, Y. Mitari, and Y. Kaneda, “Subject independent facial expression recognition with robust face detection using a convolutional neural network,” Neural Networks, vol. 16, no. 5–6, pp. 555–559, 2003, doi: 10.1016/S0893-6080(03)00115-1.

P. Baldi, “Autoencoders, Unsupervised Learning, and Deep Architectures,” ICML Unsupervised and Transfer Learning, pp. 37–50, 2012, doi: 10.1561/2200000006.

K. Simonyan and A. Zisserman, “Very deep convolutional networks for large-scale image recognition,” 3rd International Conference on Learning Representations, ICLR 2015 - Conference Track Proceedings, pp. 1–14, 2015.

J. Weston, F. Ratle, and R. Collobert, “Deep learning via semi-supervised embedding,” Proceedings of the 25th International Conference on Machine Learning, pp. 1168–1175, 2008, doi: 10.1145/1390156.1390303.

D. Erhan, A. Courville, Y. Bengio, and P. Vincent, “Why does unsupervised pre-training help deep learning?,” Journal of Machine Learning Research, vol. 9, pp. 201–208, 2010.

D. Visa Sofia, “Confusion Matrix-based Feature Selection Sofia Visa,” ConfusionMatrix-based Feature Selection Sofia, vol. 710, no. January, p. 8, 2011.

R. Wu, S. Yan, Y. Shan, Q. Dang, and G. Sun, “Deep Image: Scaling up Image Recognition,” 2015.

T. F. Gonzalez, “Handbook of approximation algorithms and metaheuristics,” Handbook of Approximation Algorithms and Metaheuristics, pp. 1–1432, 2007, doi: 10.1201/9781420010749.

U. Balasooriya and M. U. S. Perera, “Intelligent brain hemorrhage diagnosis using artificial neural networks,” BEIAC 2012 - 2012 IEEE Business, Engineering and Industrial Applications Colloquium, pp. 128–133, 2012, doi: 10.1109/BEIAC.2012.6226036.

R. Badenes and F. Bilotta, “Neurocritical care for intracranial haemorrhage: A systematic review of recent studies,” British Journal of Anaesthesia, vol. 115, no. December, pp. ii68–ii74, 2015, doi: 10.1093/bja/aev379.

F. Alobeidi and R. I. Aviv, “Basel Emergency Imaging of Intracerebral Haemorrhage,” Frontiers of Neurology and Neuroscience, vol. 37, pp. 13–26, 2015, doi: 10.1159/000437110.

J. Napier, C. J. Debono, P. Bezzina, and F. Zarb, “A CAD System for Brain Haemorrhage Detection in Head CT Scans,” EUROCON 2019 - 18th International Conference on Smart Technologies, pp. 1–6, 2019, doi: 10.1109/EUROCON.2019.8861833.

Q. Li and R. M. Nishikawa, “Computer-aided detection and diagnosis in medical imaging,” Computer-Aided Detection and Diagnosis in Medical Imaging, pp. 1–425, 2015, doi: 10.1201/b18191.

S. Yu and L. Guan, “A CAD system for the automatic detection of clustered microcalcifications in digitized mammogram films,” IEEE Transactions on Medical Imaging, vol. 19, no. 2, pp. 115–126, 2000, doi: 10.1109/42.836371.

D. Hutchison, “and Data Labeling,” vol. 2, pp. 21–29, 2016, doi: 10.1007/978-3-319-46976-8.

A. Helwan and D. Uzun Ozsahin, “Sliding Window Based Machine Learning System for the Left Ventricle Localization in MR Cardiac Images,” Applied Computational Intelligence and Soft Computing, vol. 2017, 2017, doi: 10.1155/2017/3048181.

S. Albarqouni, C. Baur, F. Achilles, V. Belagiannis, S. Demirci, and N. Navab, “AggNet: Deep Learning From Crowds for Mitosis Detection in Breast Cancer Histology Images,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1313–1321, 2016, doi: 10.1109/TMI.2016.2528120.

J. L. Nute, L. Le Roux, A. G. Chandler, V. Baladandayuthapani, D. Schellingerhout, and D. D. Cody, “Differentiation of low-attenuation intracranial hemorrhage and calcification using dual-energy computed tomography in a phantom system,” Investigative Radiology, vol. 50, no. 1, pp. 9–16, 2015, doi: 10.1097/RLI.0000000000000089.

P. M. Parizel, S. Makkat, E. Van Miert, J. W. Van Goethem, L. Van den Hauwe, and A. M. De Schepper, “Intracranial hemorrhage: Principles of CT and MRI interpretation,” European Radiology, vol. 11, no. 9, pp. 1770–1783, 2001, doi: 10.1007/s003300000800.

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Published

2022-01-31

How to Cite

Tharek, A., Muda, A. S., Baseri Hudi, A., & Baseri Hudin, A. (2022). INTRACRANIAL HEMORRHAGE DETECTION IN CT SCAN USING DEEP LEARNING. Asian Journal Of Medical Technology, 2(1), 1–18. https://doi.org/10.32896/ajmedtech.v2n1.1-18