THERMO-PNEUMATIC MICROPUMP FOR DRUG DELIVERY APPLICATIONS

Authors

  • Norihan Hamid Fakulti Kejuruteraan Elektronik dan Kejuruteraan Komputer (FKEKK), Universiti Teknikal Malaysia Melaka
  • Burhanuddin Yeop Majlis Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsan Malaysia, 43600, Bangi, Selangor, Malaysia
  • Jumril Yunas Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsan Malaysia, 43600, Bangi, Selangor, Malaysia
  • Mazree Ibrahim Fakulti Teknologi Kejuruteraan (FTK), Universiti Teknikal Malaysia Melaka, 76100 Durian Tunggal, Melaka, Malaysia

DOI:

https://doi.org/10.32896/ajmedtech.v2n1.19-34

Keywords:

thermo-neumatic, micropump, drug delivery, thin-film membrane

Abstract

Micropumps constitute an essential part of precise delivery and directional volume control of fluid in a microfluidic system. In biomedical applications, micropump is widely used especially in drug delivery, biological fluid transmission, organic analysis, liquid measurement, and many more. In this paper, the concept and design structure hence fabrication of the Thermo pneumatic micropump prototype are explained. The experimental measurement of the micropump employing planar diffuser nozzle in transmits fluid is also presented. Thermopneumatic micropump is comprised of three different components which are the microheater on the bottom, the flexible thin membrane that acts as an actuator, and the planar diffuser nozzle on the top to channel the fluidic. These three components were fabricated separately due to the different materials and techniques used in each component.  Finally, the whole micropump system was integrated using an anodic bonding technique. Bulk micromachining technique was used to fabricated the chamber and thin-film membrane, surface micromachining technique for the microheater while replica molding technique was used for the planar diffuser nozzle. The whole diameter size for the micropump was  25 x 20 x 1.6 mm respectively. The microscope image recorded video and data was used during the experimental measurement, to observed and calculate the flow rate of meniscus motion flow in the outlet tube of the micropump.  At the end of the experiment, the flow rate range of the micropump measure was approximately 770pL to 12.5nL, when the output of 2-12Vdc was applied to the microheater.  This flow rate range is very suitable for drug delivery applications.

References

J .S. Kochhar S. Y. Chan, P. S. Ong, W. G. Lee, L. Kang, Microfluidic Devices for Biomedical Applications, Woodhead Publishing Series, 2013, pp.231-280

Dennis L. Polla, Arthur G. Erdman, William P. Robbins, David T. Markus, Jorge Diaz-Diaz, Raed Rizq, Yunwoo Nam, and Hui Tao Brickner, “Microdevices in Medicine”, Annual Review of Biomedical Engineering, 2000, Vol. 2, pp. 551-576

B. Bhattaccharyya, “Electrochemical Micromachining for Nanofabrication, MEMS and Nanotechnology”, William Andrew Publication, 2015

M. W. Ashraf, S. Tayyab,N. Afzulpurkar, “Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications”, 2011, Int. J. Molecular Sciences, Vol. 12 (6), pp. 3648-3704.

Yao-Nan Wanga, Lung-Ming Fu, Yao-Nan Wanga, Lung-Ming Fu, “Micropumps and biomedical applications – A review”, J. Microelectronic Eng, 2008, Vol. 195, pp. 121-138

N. M. Elman and U. M. Upadhay, “Medical Applications of Implantable Drug Delivery Microdevices Based on MEMS (Micro-Electro-Mechanical-Systems)”, J. of Current Pharmaceutical Biotechnoloy, 2010, Vol. 11, pp. 398-404

Faranak Rajab, Alireza Bakhshi, Ghazale Kazemi, “Drug delivery applications of mechanical micropumps,”, J Conference: International Conference on Applied Researches in Science & EngineeringAt: Amsterdam, Netherlands. Jan 2021, pp. 1-18.

Agnes Bußmann, Henry Leistner, Doris Zhou, Martin Wackerle 1, Yücel Congar, Martin Richter, “Piezoelectric Silicon Micropump for Drug Delivery Applications”, J. Applied Sci. Vol. 11, 2021, pp 1-14.

Farid Amirouche, Yu Zhou & Tom Johson “Current micropump technologies and therir biomedical application”, J. Microsystem technologies, 2009, Vol.15, pp. 647-666.

D. I. Brian and V. G. Surech “Recent Advances in microscale pumping technologies: a review and evaluation Microfluidic Nanofluidic”, 2008, Vol. 5. pp.145-174.

S. R. Hwang, W. Y. Sim, D. H. Jeon, G. Y. Kim, S. S.Yang, & J. J. Park, (2005). “Fabrication and test of a sub microliter level thermopneumatic micropump for transdermal drug delivery”, 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2004, pp. 143–145.

S. Zimmermann, J. A. F. D. Liepmann & A. P. Pismo, “A Planar Micropump Utilizing Thermopneumatic Actuation and In-plane Flap Valves”, 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Sep 2004, pp. 462–465.

Manoj Pandey and P.C. Upadhyay, (2012), “Design and Simulation of Valve Less PZT Micropump for Drug Delivery System”. Int. Journal of Advancement Technology, Vol. 3, Issue 2 pp. 92-100

Stemme, G., & Stemme, E. (1993). A valveless diffuser with no nozzle-based pump. Sensor and Actuators A, 2(39), pp. 156–167

A. E. Guber, M. Heckele, D., Herrmann, A., Muslija, V. Saile, L. Eichhorn,G., Knebel. (2004). Microfluidic lab-on-a-chip systems based on polymers — fabrication and application. Chemical Engineering Journal, 2004, Vo. 101, pp .447–453.

Iverson, B. D., & Garimella, S. V. (2008). Recent Advances in Microscale Pumping Technologies: A Review and Evaluation and evaluation. Microfluidics and Nanofluidics, Vol. 5, pp. 145–174.

Nguyen, N.-T., & Truong, T.-Q. (2004). A fully polymeric micropump based on laminar technology. Journal of Micromechanics and Microengineering. Vol. 14, Issue 4, pp. 632-638.

Dau, V. T., Dinh, T. X., Tanaka, K., & Sugiyama, S. (2009). Study on the geometry of valveless-micropump. 2009 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, pp. 308–313.

Jeong, O. C., & Yang, S. S. (2000). Fabrication and test of a thermopneumatic micropump with a corrugated p+ diaphragm. Sensors and Actuators A: Physical, 83(1-3), pp.249–255.

Agnes B. B, Lorenz M. G, Claudia P. D, Thomas A. T, Axel W, Martin Richtera. (2021) “Microdosing for drug delivery application—A review”, Sensor and Actuators A, , Vol. 330, pp. 1-26.

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Published

2022-01-31

How to Cite

Hamid, N., Majlis, B. Y., Yunas, J., & Ibrahim, M. (2022). THERMO-PNEUMATIC MICROPUMP FOR DRUG DELIVERY APPLICATIONS. Asian Journal Of Medical Technology, 2(1), 19–34. https://doi.org/10.32896/ajmedtech.v2n1.19-34