• S.C. Nwaneri Department of Biomedical Engineering, Faculty of Engineering, University of Lagos, 132, Akoka Yaba, Lagos, Nigeria
  • B.N. Ezenwa Department of Paediatrics, College of Medicine, 132, Akoka Yaba, Lagos, Nigeria
  • A.A. Osuntoki Department of Biochemistry, College of Medicine, 132, Akoka Yaba, Lagos, Nigeria
  • V.C. Ezeaka Department of Paediatrics, College of Medicine, 132, Akoka Yaba, Lagos, Nigeria
  • D.W. Gatchell Department of Biomedical Engineering, Northwestern University, 60208, Evanston, Illinois, United States of America
  • F.T. Ogunsola Department of Medical Microbiology and Parasitology, College of Medicine, 132, Akoka Yaba, Lagos, Nigeria



Infant Apnoea, Preterm, Internet of Things, Neonatal Hypertension, Pulse Oximetry Sensor


Apnoea is a common disorder in preterm infants who may also suffer from neonatal hypertension. Conventional apnoea monitors used in neonatal intensive care units (NICUs) do not include features for measuring neonatal blood pressure and real-time remote monitoring. Smart devices to monitor this problem in resource-poor environments are expensive and sparsely available. This paper presents the development of a smart multiparameter infant apnoea monitor in a resource-poor setting. The circuit was designed and simulated in Proteus software. The signals were processed using Arduino mega microcontrollers. The microcontroller concurrently communicates apnoea events to the GSM modem and alarm which notify the doctor and caregivers by SMS alert and audible alarm, respectively. Preliminary testing on stable infants at the NICU of Lagos University Teaching Hospital showed promising results. The device can effectively be used to monitor apnoea in infants as well as transmit the results to the doctor in a remote location by SMS. It can also be used to monitor other parameters like oxygen saturation, respiratory rate, heart rate and blood pressure. The documented experiences will provide useful insights for smart infant apnoea monitor development in resource-poor environments.


J.A. Dempsey, S.C. Veasey, B.J. Morgan, C.P. O'Donnell, "Pathophysiology of Sleep Apnea", Physiological Reviews, 90, pp. 47 – 112, 2010.

S. Picone, R. Aufieri, P. Paolillo, "Apnea of prematurity: challenges and solutions", Research and Reports in Neonatology, vol. 4, pp. 101 - 109, 2014.

J.M. Rennie N.R. Robertson, Apnoiec attacks, In: J.M. Rennie, G. Kendall (Eds.), A manual of neonatal intensive care, fourth ed., Arnold Publishers, Oxford, pp. 216 – 222, 2002.

C.L. Huddy, A. Johnson, P.L. Hope, "Educational and behavioral problems in babies of 32–35 weeks gestation", Archives of Disease in Childhood (Fetal Neonatal Ed.), vol. 85, 23F-8, 2001.

A. Tamene, G. Abeje, and Z. Addis, "Survival and associated factors of mortality of preterm neonates admitted to Felege Hiwot specialized hospital, Bahir Dar, Ethiopia", Sage Open Medicine, 2020,

T.A. Ogunlesi, O.B. Ogunfowora, "Pattern and determinants of newborn apnea in an under-resourced Nigerian setting", The Nigerian Journal of Clinical Practice, vol. 15, pp. 159 – 164, 2012.

A. Janvier, M. Khairy, A. Kokkotis, C. Cormier, D. Messmer, K.J. Barrington, "Apnoea is associated with neurodevelopmental impairment in very low birth weight infants", Journal of Perinatology, vol. 24, pp. 763 – 768, 2004.

NL. Maitre, R.A. Ballard, J.H. Ellenberg, S.D. Davis, J.M. Greenberg, A. Hamvas, G.S. Pryhuber, "Respiratory consequences of prematurity: evolution of a diagnosis and development of a comprehensive approach", Journal of Perinatolology, vol. 35, no. 5, pp. 313 – 321, 2015.

R.H. Steinhorn, "Neonatal Pulmonary Hypertension", Pediatric Critical Care Medicine, vol. 11, pp. 79 – 84, 2010.

[10] A. Nickavar, F. Assadi, "Managing Hypertension in the Newborn Infants". International Journal of Preventive Medicine, vol. 5, no. 1, pp. S39 - S43, 2014.

S. Cunningham, A.G. Symon, R.A. Elton, "Intra-arterial blood pressure reference ranges, death and morbidity in VLBW infants in the first 7 days of life", Early Human Development, vol. 56, pp. 151 – 156, 1999.

MD. Biase, A. Casani, L. Orfeo, "Invasive arterial blood pressure in the neonatal intensive care: a valuable tool to manage very ill preterm and term neonates", Italian Journal of Pediatrics, vol. 41(suppl 1), 2015 doi: 10.1186/1824-7288-41-S1-A9.

N. Kumar, G. Akangire, B. Sullivan, et al. "Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront". Pediatric Research, vol. 87, pp. 210–220, 2020,

S. Seifi, A. Khatony, G. Moradi, A. Abdi, F. Najafi, "Accuracy of pulse oximetry in detection of oxygen saturation in patients admitted to the intensive care unit of heart surgery: comparison of finger, toe, forehead and earlobe probes", BMC Nursing, vol. 17, no. 15, 2018,

A. Abrishami, A. Khajehdehi, F. Chung, "A systematic review of screening questionnaires for obstructive sleep apnea", Canadian Journal of Anesthesia, vol. 57, no. 5, pp. 423 – 438, 2010.

S.M. Caples, W. M. Anderson, K. Calero, M. Howell, SD. Hashmi. Use of polysomnography and home sleep apnea tests for the longitudinal management of obstructive sleep apnea in adults: an American Academy of Sleep Medicine clinical guidance statement. Journal of Clinical Sleep Medicine, vol. 17, no. 6, pp. 1287-1293, 2021, doi: 10.5664/jcsm.9240.

A. Roebuck, V. Monasterio, E. Gederi, M. Osipov, J. Behar, A. Malhotra, T. Penzel, G.D. Clifford, "A review of signals used in sleep analysis", Physiological Measurement, vol. 35, pp. R1 – 57, 2014.

Y. Fang, Z. Jiang, H. Wang, "A Novel Sleep Respiratory Rate Detection Method for Obstructive Sleep Apnea Based on Characteristic Moment Waveform", Journal of Healthcare Engineering, 2018,

M. Kapoor, G. Greenough, Home, "Sleep Tests for Obstructive Sleep Apnea (OSA)", Journal of the American Board of Family Medicine, vol. 28, no. 4, pp. 504 – 509, 2015.

N. Oliver, F. Flores-Mangas, "HealthGear: Automatic Sleep Apnea Detection and Monitoring with a Mobile Phone", Journal of Communications, vol. 2, no. 2, pp. 1 – 9, 2007.

A. Yadollahi, E. Giannouli, Z. Moussavi, "Sleep apnea monitoring and diagnosis based on pulse oximetry and tracheal sound signals", Medical and Biological Engineering and Computing, vol. 48, pp. 1087–1097, 2010.

A. R. Dhruba, K.N. Alam, S. Khan, S. Bourouis, M.M. Khan, "Development of an IoT Based Sleep Apnea Monitoring System for Health Applications", vol. 2021, Article 7152576 16 pages, 2021,

S.R. Sawale, V.S. Gulhane, "Multimodality Sensor System for Sleep - Quality Monitoring", International Journal of Computer Science and Mobile Computing, vol. 3, pp. 564 – 571, 2014.

M. Gaiduk, L. Weber, A.S. Alarcon, R. Seepold, N.M. Madrid, S. Orcioni, and M. Conti, "Design of a sleep apnoea detection system for a home environment", Procedia Computer Science, vol. 192, pp. 3225 – 3234, 2021.

G. Cay and K. Mankodiya, "SleepSmart: smart mattress integrated with e-textiles and IoT functions for sleep apnea management," in 2020 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops), pp. 1-2, Austin, USA, 2020.

BK. Bhoomika, K.N. Muralidhara, "Secured Smart Health Monitoring System Based on IoT" International Journal on Recent Innovation Trends in Computing and Communication, vol. 3, no. 7, pp. 4958 -4961, 2015.

BS. Ranjitha, "Non-invasive sleep apnea detection and monitoring system", International Research Journal of Engineering and Technology, vol. 3, pp. 1196 – 1202, 2016.

Garde, A Dehkordi, P Karlen, W Wensley, D Ansermino, JM and Dumont, GA (2014) "Development of a Screening Tool for Sleep Disordered Breathing in Children Using the Phone Oximeter", PLUS ONE,

N. Tewel, "Application of MEMS accelerometer for baby apnea monitoring under home conditions", Acta Bio-Optica et Informatica Medica, vol. 16, pp. 389 – 393, 2010.

Nigerian Communication Commission, "Active Internet Subscriptions by Technology January 2021 – December 2021",, 2022 (accessed 3 February 2022).

RF Tinder, "Relativistic Flight Mechanics and Space Travel: A Primer for Students, Engineers and Scientists", Morgan & Claypool Publishers, California, 2007.

G. Ciuti, L. Ricotti, A. Menciassi, P. Dario, "MEMS Sensor Technologies for Human Centred Applications in Healthcare, Physical Activities, Safety and Environmental Sensing: A Review on Research Activities in Italy", Sensors, vol. 15, pp. 6441 – 6468, 2015.

A.V. Bakshi U.A. Bakshi, "Instrumentation", Technical Communications, Pune, 2009.

J. G. Webster, Ed., Design of Pulse Oximeters, 1st ed. Taylor & Francis, 1997.

Chandrasekhar, A Kim, C Naji, M Natarajan, K Hahn, J and Mukkamala, R (2018) "Smartphone-based blood pressure monitoring via the oscillometric finger pressing method", Science Translation Medicine.

C.F. Babbs, "Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model", Biomedical Engineering Online, vol. 11, 2012,

S. Lopez, Blood Pressure Monitor Fundamentals and Designs, Free Scale Semiconductor Eichenwald, EC Committee on Fetus and Newborn, "Apnoea of prematurity". Pediatrics, vol. 137, 1, e20153757, 2012.

A. Chandrasekhar, M. Yavarimanesh, J.O. Hah, S.H. Sung, C.H. Chen, H.M. Cheng, R. Mukkamala. "Formulas to Explain Popular Oscillometric Blood Pressure Estimation Algorithms". Frontiers in Physiology, vol. 10, 1415, 2019,

A H. Abd, "Design and simulation of 4th order active bandpass filter using multiple feedback and Sallen-key topologies", Journal of Babylon University of Engineering Sciences, vol. 22, 2014, ceca8bad4ee05e7c (

S.W. Smith, The Scientist and Engineer's Guide to Digital Signal Processing, California Technical Publications, California, 1999.

S.B. Amin and E. Burnell, "Monitoring Apnea of Prematurity: Validity of Nursing Documentation and Bedside Cardiorespiratory Monitor", American Journal of Perinatology, vol. 30, pp. 643 – 648, 2013.

G.Sathiyabama,G.Vinudevi, R. Abhilashini, P.Indhupriya, "A Survey on Instrumentation Amplifiers used for Biomedical Application", International Journal of Advanced Research in Electrical and Electronics Instrumentation Engineering, vol. 4, 2015.




How to Cite

Nwaneri, S., Ezenwa, B., Osuntoki, A., Ezeaka, V., Gatchell, D., & Ogunsola, F. (2022). SMART MULTIPARAMETER INFANT APNOEA MONITOR . Asian Journal Of Medical Technology, 2(2), 15–32.