IN-VITRO HEMODYNAMICS EVALUATION OF PROLAPSE AND PERFORATED MITRAL VALVE MODEL

Abstract

The mitral valve is one of the important parts of the heart valve that prevents blood from regurgitating into the left atrium. Mitral regurgitation is the most common cause of regurgitation, affecting approximately 176 million people worldwide and 2-3% of the general population. Flow dynamics parameters are important for regurgitation severity evaluation, that can be done by flow simulation. However, there are limited open access datasets available for validating the simulated output. This paper presented an experimental setup that can serve as validation tool for flow simulation output. The in-vitro setup was tested with evaluation of flow behaviour through a defective mitral heart valve. The results shows consistent readings validated against published data. The correlations between flow rate and pressure difference between the left ventricle and left atrium conform to the principles of flow through orifice in fluid dynamics. Hence, this in-vitro setup can be utilized as a validation tool for flow simulation results expecially related to hear valve.